Especially with AutoCAD DWG files there is a big problem. As soon as a DWG is opened, AutoCAD creates two lock files. These two files and also the opened DWG cannot be synchronized. If several DWGs are opened at the same time, OneDrive may not synchronize at all. It eats away at the opened files and no other synchronizations take place.
It would make sense to ignore the opened files and instead process everything else that can still be synchronized.